Convergent synthesis of arisugacin skeletons and their acetylcholinesterase inhibitory activity.
نویسندگان
چکیده
In the course of our screening of microbial metabolites that inhibit the activity of acetylcholinesterase (AchE), we isolated potent and selective inhibitors of AchE, arisugacin A (1) and B (2) from the culture broth of Penicillium sp. FO-42591~4^ together with the structurally related known compound, territrem B (3) (Fig. 1)5'6). Interestingly, structures 1-3 resemble the pyripyropene A (4), which
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 54 4 شماره
صفحات -
تاریخ انتشار 2001